The Bioactive Effects of Sesame Seeds on Atherosclerosis and Inflammation in Rats.

Document Type : Original Article

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Nutrition and Food Science Dep., Faculty of Home Economics Helwan University, Cairo – Egypt.

Abstract

This study was carried out to investigate the bioactive effects of sesame seeds against inflammation and atherosclerotic rats.  Adult male Sprague- Dawley strain rats (n= 72) were divided into two main groups, the first main group (n=9) was fed on basal diet as a negative control group. Atherosclerosis was induced in the second main group (n = 63) which was assigned to groups 2-8. Group 2 was positive control group; the others were treated with raw, roasted and fermented sesame seeds respectively each at two levels of intake (100 and 150 gm/kg diet).  At the end of the experimental period (8 weeks), blood samples were collected for assessing liver and kidney functions, serum vitamin E and serum oxidative stress markers.Pedal inflammation was induced by 0.1 ml formalin (4%) in atherosclerotic rats and paw's thickness was recoded.  Liver from all rats were collected for histological studies.Results revealed that supplementation with forms of sesame seeds improved atherogenic index as well as caused an improvement in AST enzyme at the tested levels of intake compared with the positive control group as well as the activity of oxidative enzymes in the atherosclerotic rats,resulted in marked increase in SOD concentrations compared with positive control group.  Results showed that the addition of sesame seeds led to a significant improvement in pedal after 3, 6 hrs., 1 day, 2 day, 4 day, and 6 days of inducing inflammation .In view of the positive effect of raw, roasted and fermented sesame seeds on most of the studied parameters, the present study recommends increasing the consumption of sesame seeds in the different forms. Nutrition education programs are needed to clarify the importance of sesame seeds in reducing inflammation and combating complication of atherosclerosis. Further studies are required to evaluate the health benefits of consuming fermented sesame seeds.

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